At east four people were killed and 15 others injured in Russian and Syrian air raids on the rebel-held eastern half of the city of Aleppo.

The attack have forced the closure of the largest hospital in the area, the BBC reported on Sunday.

The Syrian American Medical Society, which supports the hospital, said it had been struck by barrel bombs.

There are also reports of Russian-backed Syrian government forces hitting Aleppo's historic Old City.

Clashes between government troops and rebels are occurring in several areas.

Russian and Syrian air forces resumed attacks on the rebel-held east of the city after a partial truce lapsed on 19 September. Government forces have also launched a ground offensive against the rebels.

Source: MENA