Lock Courtney Lawes and full-back Mike Brown have been recalled for England's Six Nations clash with Scotland on Saturday after recovering from injury, head coach Stuart Lancaster announced on Wednesday.
Northampton forward Lawes has returned to fitness after an ankle problem and is in line to make his first international appearance since England's 26-17 victory over Australia last November.
Harlequins number 15 Brown sat out England's 19-9 defeat by Ireland last time out after suffering concussion in the 47-17 win over Italy, with Alex Goode having taken his place.
Goode drops to the bench, where tighthead prop Kieran Brookes, second-row forward Geoff Parling and flanker Tom Wood have all been drafted into the match-day squad.
"There's always a lot of competition for places and having experienced players like Courtney, Tom and Geoff available after playing well for their clubs in the last few weeks adds to our options," Lancaster said in a statement on the England Rugby website.
"It's been an intense two weeks of training as everyone wants to be on that field on Saturday and we've had to make some tough selection calls."
Brown's return is a significant fillip for Lancaster, whose side missed the all-action Quins man's aggression and inventiveness at the Aviva Stadium.
Lawes replaces George Kruis, who drops out of the squad, and will reprise the second-row partnership with Dave Attwood that England deployed throughout the end-of-year internationals.
Brookes has recovered from a hip problem, while Wood is back after an ankle injury and comes in for Tom Croft, who has been sidelined by a dislocated shoulder.
The experienced Parling replaces Nick Easter and provides Lancaster with a specialist second-row option on the bench.
England's loss in Dublin on March 1 left them two points below leaders Ireland in the table, while Scotland are bottom following successive losses to France, Wales and Italy.
"Coming back to Twickenham will be huge for us and we are determined to put in a performance against a strong and motivated Scotland team," Lancaster added.
England team announced on Wednesday to play Scotland in the Six Nations at Twickenham on Saturday (1700 GMT kick-off):
England (15-1)
Mike Brown; Anthony Watson, Jonathan Joseph, Luther Burrell, Jack Nowell; George Ford, Ben Youngs; Billy Vunipola, Chris Robshaw (capt), James Haskell; Courtney Lawes, Dave Attwood; Dan Cole, Dylan Hartley, Joe Marler
Replacements: Tom Youngs, Mako Vunipola, Kieran Brookes, Geoff Parling, Tom Wood, Richard Wigglesworth, Danny Cipriani, Billy Twelvetrees
Source: AFP