A two-run homer by Jesus Guzman snapped a tie and touched off a six-run eighth inning Friday that brought the San Diego Padres a 7-1 victory over Arizona. The Padres, owners of the worst record in the majors, ended a six-game losing streak. With starter Wade Miley still in the game, Alexi Amarista reached on a one-out bunt single in the eighth and Guzman broke a 1-1 tie with his homer to left-center. The next six San Diego batters all reached base with the final two runs of the inning scoring on a fielding error by right fielder Justin Upton. Andrew Cashner (3-3) worked the top of the eighth to get the win, allowing a walk and striking out one. Miley (6-2) wound up going 7 1/3 innings, giving up four runs on six hits.