Six-time champions Boca Juniors were Friday drawn to play Paraguay's Cerro Porteno in the Copa Libertadores round of 16.

The Argentine outfit, who finished top of group 3 with 12 points from six matches, will travel to Asuncion on April 28 before the return match at their Bombenera stadium on May 5.

Cerro Porteno qualified for the knockout phase by finishing second in Group 8 with 10 points.

Meanwhile defending champions River Plate have been drawn against Ecuador's Independiente del Valle.

River, who topped Group 1 with 11 points, will travel to Quito for the first leg on April 28 with the return fixture at the Monumental on May 4.

Colombia's Atletico Mineiro, who finished the group phase with a competition-high 16 points, will meet Argentina's Huracan in Buenos Aires on April 26 and then in Medellin on May 3.

Three-time Copa Libertadores title winners Nacional of Uruguay will confront reigning Brazilian Serie A champions Corinthians at home on April 27 and away on May 4.

Copa Libertadores Round of 16

First leg:

April 26

19.30. Huracan vs. Atletico Nacional

21.45. Tachira vs. Pumas

April 27

19.30. Racing vs. Atletico Mineiro

21.45. Nacional vs. Corinthians

21.45. Gremio vs. Rosario Central

April 28

19.30. Independiente del Valle vs. River

21.45. Cerro Porteno vs. Boca

21.45. San Pablo vs. Toluca

Second leg:

May 3

21.45. Atletico Nacional vs. Huracan

23.45. Pumas vs. Tachira

May 4

19.15. River vs. Independiente del Valle

19.15. Toluca vs. San Pablo

21.45. Atletico Mineiro vs. Racing

21.45. Corinthians vs. Nacional

May 5

19.15. Rosario Central vs. Gremio

21.45. Boca vs. Cerro Porteno